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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Enhanced associated movements in the contralateral limbs elicited by brisk voluntary contraction in choreic disorders.
    Author: Hashimoto T, Shindo M, Yanagisawa N.
    Journal: Clin Neurophysiol; 2001 Sep; 112(9):1612-7. PubMed ID: 11514243.
    Abstract:
    OBJECTIVES: To study the deficit of inhibition of excessive motor drive generated in the central nervous system in chorea. METHODS: Identical associated movements in the contralateral limb elicited by rapid hand squeezing were measured in 6 patients with Huntington's disease, 7 patients with peak-dose dyskinesia, 10 patients with Parkinson's disease, 8 patients with spinocerebellar degeneration and in 8 normal subjects. The intensity of associated movements was assessed by the EMG amplitude ratio of associated contractions to active contractions. RESULTS: The associated movement ratios were larger in Huntington's disease and peak-dose dyskinesia as compared to other groups. The ratios in akinetic "off" phase were smaller than those in dyskinetic "on" phase in all peak-dose dyskinesia patients. CONCLUSIONS: Enhanced associated movements support a possible common mechanism that chorea may result from failure in inhibition of phasic neural activity pathologically generated in the brain.
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