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  • Title: Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice.
    Author: Sinha S, Murugesan T, Pal M, Saha BP.
    Journal: Phytomedicine; 2001 Jul; 8(4):298-301. PubMed ID: 11515720.
    Abstract:
    The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.
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