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  • Title: Pressor response to unilateral carotid chemoreceptor activation is not affected by ipsilateral antagonism of excitatory amino acid receptors in the rostral ventrolateral medulla of awake rats.
    Author: Mauad H, Machado BH.
    Journal: Auton Neurosci; 2001 Aug 13; 91(1-2):26-31. PubMed ID: 11515798.
    Abstract:
    The importance of the integrity of the ipsilateral rostral ventrolateral medulla (RVLM) in the pressor response to activation of unilateral arterial chemoreceptors was evaluated. To achieve this goal, the left carotid body artery was ligated prior to the experiment and a guide cannula was implanted in the direction of the right RLVM, i.e. the side where the carotid body artery was kept intact. On the day of the experiment, the chemoreflex was activated with potassium cyanide (KCN, i.v.) before and after unilateral microinjection of kynurenic acid into the rostral or caudal aspect of the RVLM. The data indicated that microinjection of kynurenic into the rostral or caudal aspect of the RVLM produced no effect on the pressor response of chemoreflex activation. These data suggest that chemoreflex activation excites a neuronal network in which the processing of the sympatho-excitatory component of the chemoreflex is not restricted to an excitatory projection from the nucleus tractus solitarii to the ipsilateral RVLM.
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