These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: New synthesis of (RS)-carnitine chloride.
    Author: Boots SG, Boots MR.
    Journal: J Pharm Sci; 1975 Jul; 64(7):1262-4. PubMed ID: 1151695.
    Abstract:
    A four-step synthesis of (RS)-carnitine chloride was developed using extremely mild reaction conditions and versatile intermediates. Crotyl chloride was converted to tert-butyl 3-butenoate using tert-butyl alcohol and triethylamine in ether. Treatment of tert-butyl 3-butenoate with m-chloroperbenzoic acid in chloroform afforded tert-butyl 3,4-epoxybutyrate. Reaction of this compound with trimethylamine hydrochloride in methanol, followed by mild acid hydrolysis of the tert-butyl ester, afforded (RS)-carnitine chloride.
    [Abstract] [Full Text] [Related] [New Search]