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  • Title: [cGMP-independent effect of nitric oxide on contractility and intracellular calcium level of rat tail artery vascular smooth muscles].
    Author: Solovĭov AI, Lehen'kyĭ VV, Zelens'kyĭ SM, Moĭbenko OO, Stefanov OV.
    Journal: Fiziol Zh (1994); 2001; 47(3):19-25. PubMed ID: 11519245.
    Abstract:
    The effects of nitric oxide (NO, 10(-6) M) on contractility and intracellular calcium level ([Ca2+]i) of rat tail artery smooth muscles in control and under inhibition of soluble guanylate cyclase (sGC) with 6-anilino-5,8-quinolinedione (LY83583, 10(-6) M) are investigated. NO-induced relaxations of vascular smooth muscles comprised 61.01 +/- 5.56% of maximum induced amplitude of K(+)-contracture, and decreases in [Ca2+]i comprised 66.35 +/- 11.33%. Under the inhibition of sGC with LY83583 NO-induced relaxations of vascular smooth muscles comprised 29.41 +/- 5.17% of maximum induced amplitude of K(+)-contracture, and decreases in [Ca2+]i comprised 53.68 +/- 16.93%. Thus, cGMP-independent relaxation of vascular smooth muscle and decrease in [Ca2+]i of rat tail artery is confirmed.
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