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  • Title: NO donor SIN-1 potentiates monosynaptic reflexes in the cat spinal cord.
    Author: Manjarrez E, Rocha T, Rojas-Piloni G, Méndez I, Vélez D, Flores A.
    Journal: Neuroreport; 2001 Aug 28; 12(12):2667-71. PubMed ID: 11522945.
    Abstract:
    The effect produced by the nitric oxide donor SIN-1 on monosynaptic reflexes was examined. Experiments were performed on anesthetized, paralyzed and spinalized cats. Lumbar monosynaptic reflexes were produced by stimulation of Ia afferents. I.v. application of SIN-1 (500 microg/kg) produced a mean marked potentiation of 704% of pre-drug control (100%) in the amplitude of monosynaptic reflexes. In addition, in other experiments a concentration-dependent effect on the amplitude of monosynaptic reflexes was observed after microinjections of SIN-1 into the ventral horn (1 microl; 10(-12) - 10(-3) M), with a mean facilitatory effect of 355%. In both cases, the potentiation was reversible 45 min after i.v. or local application of SIN-1. These results provide the first evidence that monosynaptic reflexes can be potentiated by nitric oxide.
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