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  • Title: Effect of food on the bioavailability of 100-mg dilantin Kapseals.
    Author: Cook J, Randinitis E, Wilder BJ.
    Journal: Neurology; 2001 Aug 28; 57(4):698-700. PubMed ID: 11524482.
    Abstract:
    The authors examined the effect of food on the bioavailability of Dilantin Kapseals in a nonblinded, single 100-mg dose, randomized, crossover trial. Drug was administered after an 8-hour fast and after a high-fat meal. Differences in mean dietary state values were +6% for maximum concentrations (C(max)) and -2% for area under the curve. Associated 90% CI were within US Food and Drug Administration criteria, confirming the absence of a food effect. Thus, patients may take 100-mg Dilantin Kapseals without regard to meals.
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