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  • Title: Diagnosis of HAM/TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index.
    Author: Puccioni-Sohler M, Rios M, Carvalho SM, Gonçalves RR, Oliveira C, Correa RB, Novis S, de Oliveira MS, Bianco C.
    Journal: Neurology; 2001 Aug 28; 57(4):725-7. PubMed ID: 11524492.
    Abstract:
    The contribution of human T-cell lymphotropic virus (HTLV-I) DNA by PCR in CSF and the intrathecal synthesis of antibodies to HTLV-I by the antibody index (AI) to the diagnosis of HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) were evaluated. Cases of spastic paraparesis compatible with HAM/TSP had increased AI for HTLV-I (60/73) and HTLV-I proviral sequences in CSF (25/27). Among 27 patients with other neurologic diseases, three had increased AI and another three had positive HTLV-I DNA in CSF. Thus, the combination of PCR for proviral DNA and AI for HTLV-I in CSF provides consistent criteria for the diagnosis of HAM/TSP.
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