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  • Title: Cutaneous necrobiotic xanthogranuloma (NXG)--successfully treated with low dose chlorambucil.
    Author: Machado S, Alves R, Lima M, Leal I, Massa A.
    Journal: Eur J Dermatol; 2001; 11(5):458-62. PubMed ID: 11525957.
    Abstract:
    We report a case of necrobiotic xanthogranuloma in a 51 year-old white male patient presenting with a 6-year history of multiple indurated violaceous nodules and plaques involving the eyelids, trunk and extremities. He had an associated paraproteinemia (Ig G lambda), elevated sedimentation rate, cryoglobulinemia and hypocomplementemia. No extracutaneous involvement was detected. He was successfully treated with chlorambucil (2 mg/d for 7 months), leading to disappearance of all skin lesions.
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