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  • Title: The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite.
    Author: Reddick JJ, Saha S, Lee J, Melnick JS, Perkins J, Begley TP.
    Journal: Bioorg Med Chem Lett; 2001 Sep 03; 11(17):2245-8. PubMed ID: 11527707.
    Abstract:
    The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-methoxy-thiamin pyrophosphate inhibits alpha-ketoglutarate dehydrogenase, transketolase, and deoxy-D-xylulose-5-phosphate synthase. Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes.
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