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  • Title: Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
    Author: Dener JM, Wang VR, Rice KD, Gangloff AR, Kuo EY, Newcomb WS, Putnam D, Wong M.
    Journal: Bioorg Med Chem Lett; 2001 Sep 03; 11(17):2325-30. PubMed ID: 11527724.
    Abstract:
    Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with K(i) values ranging from 0.084 to 0.21 microM against the enzyme.
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