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  • Title: Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity.
    Author: Li MX, Jia M, Jiang H, Dunlap V, Nelson PG.
    Journal: Nat Neurosci; 2001 Sep; 4(9):871-2. PubMed ID: 11528415.
    Abstract:
    A compartmental nerve-muscle tissue culture system expresses Hebbian activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.
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