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  • Title: Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura.
    Author: Besbas N, Duzova A, Topaloglu R, Gok F, Ozaltin F, Ozen S, Bakkaloglu A.
    Journal: Clin Rheumatol; 2001; 20(4):293-6. PubMed ID: 11529643.
    Abstract:
    Henoch-Schönlein purpura (HSP) is the most common vasculitis in children. It is a multisystemic disease but pulmonary haemorrhage is extremely rare. We present the case of a 6-year-old boy with Henoch-Schönlein purpura, pulmonary haemorrhage and severe renal involvement. The patient responded to a combination of intravenous methylprednisolone and cyclophosphamide. A review of the literature revealed that young age may be a good prognostic sign and that immunosuppressive drugs and supportive management are essential in the treatment. Renal biopsy is helpful in the differential diagnosis of HSP-mimicking pulmonary vasculitic syndromes. Combining cyclophosphamide with glucocorticoids may improve the outcome in severe HSP cases with pulmonary haemorrhage.
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