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  • Title: De novo initiation of viral RNA-dependent RNA synthesis.
    Author: Kao CC, Singh P, Ecker DJ.
    Journal: Virology; 2001 Sep 01; 287(2):251-60. PubMed ID: 11531403.
    Abstract:
    RNA viruses use several initiation strategies to ensure that their RNAs are synthesized in appropriate amounts, have correct termini, and can be translated efficiently. Many viruses with genomes of single-stranded positive-, negative-, and double-stranded RNA initiate RNA synthesis by a de novo (primer-independent) mechanism. This review summarizes biochemical features and variations of de novo initiation in viral RNA replication.
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