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  • Title: Plasma thyrotropin-releasing hormone, prolactin, thyrotropin, and thyroxine concentrations following the intravenous or oral administration of thyrotropin-releasing hormone.
    Author: Andreassen B, Huth J, Tyson JE.
    Journal: Am J Obstet Gynecol; 1979 Nov 15; 135(6):737-42. PubMed ID: 115316.
    Abstract:
    In a further evaluation of the use of oral thyrotropin-releasing hormone (TRH) in puerperally lactating women, a radioimmunoassay for its measurement has been developed. Its concentration in plasma as well as that of prolactin (PRL), thyrotropin (TSH) and thyroxine (T4) were measured following either intravenous or oral administration of TRH. Basal concentrations of TRH in 14 normally cycling women ranged from less than 5 to 17 pg/ml. Two luteal phase studies produced peaks in plasma TRH 5 to 10 minutes after 100 micrograms of TRH administered intravenously with a return to basal concentrations within 2 to 3 hours. In 10 normally menstruating women, ingestion of 10 mg of TRH orally resulted in plasma TRH which peaked at 423 +/- 123 pg/ml (standard error of the mean) at 30-minutes. Plasma PRL, TSH, and T4 also increased and remained slightly elevated at 4 hours. These 8-hour studies were performed in a puerperal lactating woman who had ingested 10 mg of TRH orally twice a day for 7 days prior to blood sampling. TRH concentrations declined throughout each day while TSH rose slightly in the first 1 to 2 hours but remained within normal limits. The prolonged administration of 10 mg of TRH orally twice daily to three puerperally lactating women resulted in elevations in plasma TRH 2 to 3 hours following hormone administration, yet no significant increases in plasma TSH were observed. Both endogenous TRH and TSH were measured before and after 22 nursing events in nine puerperally lactating women. There was no change in the concentration of either substance and all values were similar to those obtained in normally menstruating women. A radioimmunassay was developed and is described for use in evaluating the effect of oral thyrotropin-releasing hormone (TRH) in puerperally lactating women. After either intravenous or oral administration, TRH plasma levels, prolactin, thyrotropin (TSH), and thyroxine (T4) levels were measured by this radioimmunoassay. Basal concentrations of TRH in 14 normally cycling women ranged from 5-17 pg/ml. Peaks in plasma TRH were produced in 2 luteal-phase studies 5-10 minutes after 100 mcg of TRH was administered intravenously, returning to basal concentrations within 2-3 hours. 10 normally menstruating women ingested 10 mg of TRH orally; plasma TRH peaked at 423 pg/ml at 30 minutes. Plasma prolactin, TSH, and T4 levels also increased and remained slightly elevated at 4 hours. 8-hour studies were performed in a puerperal lactating woman who had ingested 10 mg of TRH orally 2 times/day for 7 days before blood sampling. TRH levels declined throughout each day, whereas TSH rose slightly in the 1st 1-2 hours but remained within normal limits. Prolonged ingestion of 10 mg of TRH 2 times/day was studied in 3 puerperally lactating women and resulted in elevations in plasma TRH 2-3 hours after hormone administration, but no significant increases in plasma TSH were observed. Both endogenous TRH and TSH were measured before and after 22 nursing events in 9 puerperally lactating women, and there was no change in the level of either substance; all values were similar to those obtained from normally menstruating women.
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