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  • Title: Effect of calcium bodesilate (doxium) on circulatory disorders of the retina with special emphasis on diabetic retinopathy.
    Author: Németh B, Hudomel J, Farkas A.
    Journal: Ophthalmologica; 1975; 170(5):434-45. PubMed ID: 1153166.
    Abstract:
    The authors examined the effect of calcium dobesilate (Doxium ¿) on 85 subjects with diabetic retinopathy, occlusion of the central vein of the retina and other retinopathies of vascular origin. Capillary resistance measured on the skin and conjunctiva showed, as compared with 100 healthy subjects, a significant decrease. The efficacy of long-term treatment with Doxium was highly significant in restoring CR to normal. Visual acuity improved in 45.8% of simple DR cases, and became stabilized in 27.5% of cases with malignant DR. Hyperpermeability of retinal vessels decreased in 60% of simple DR cases. It is pointed out that glaucoma did not develop in cases of venous occlusion and the diagnostic value of capillary resistance measurement in diabetes. As a highly effective vasoprotective drug, Doxium¿ is the treatment of choice in all retinopathies of vascular etiology.
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