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  • Title: Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups.
    Author: Greene GL, Letsinger RL.
    Journal: Nucleic Acids Res; 1975 Jul; 2(7):1123-7. PubMed ID: 1153331.
    Abstract:
    The stepwise synthesis of oligomers derived from 5'-amino-5'-deoxythymidine 3'-phosphate and 5'-amino-5'-deoxy-3'-O-mono-p-methoxytrityl-thymidine is described. The internucleotide phosphoramidate links were formed by condensation of nucleoside 3'-phosphates with aminonucleosides by means of triphenylphosphine and dipridyl disulfide.
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