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  • Title: Changes in extracellular muscle volume affect heart rate and blood pressure responses to static exercise.
    Author: Baum K, Essfeld D, Stegemann J.
    Journal: Acta Astronaut; 1991; 23():139-47. PubMed ID: 11537116.
    Abstract:
    To investigate the effect of microgravity-induced peripheral extracellular fluid reductions on heart rate and blood pressure during isometric exercise, six healthy male subjects performed three calf ergometer tests with different extracellular volumes of working muscles. In all tests, body positions during exercise were identical (supine with the knee joint flexed to 90 degrees). After a pre-exercise period of 25 min, during which calf volumes were manipulated, subjects had to counteract an external force of 180 N for 5 min. During the pre-exercise period three different protocols were applied. Test A: Subjects rested in the exercise position; test B: Body position was the same as in A but calf volume was increased by venous congestion (cuffs inflated to 80 mm Hg); test C: Calf volumes were decreased by a negative hydrostatic pressure (calves about 40 cm above heart level with the subjects supine). To clamp the changed calf volumes in tests B and C, cuffs were inflated to 300 mm Hg 5 min before the onset on exercise. This occlusion was maintained until termination of exercise. Compared to tests A and B, the reduced volume of test C led to significant increases in heart rate and blood pressure during exercise. Oxygen uptake did not exceed resting levels in B and C until cuffs were deflated, indicating that exclusively calf muscles contributed to the neurogenic peripheral drive. It is concluded that changes in extracellular muscle volume have to be taken into account when comparing heart rate and blood pressure during 1g- and microgravity-exercise.
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