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  • Title: Was adenine the first purine?
    Author: Schwartz AW, Bakker CG.
    Journal: Science; 1989 Sep 08; 245():1102-4. PubMed ID: 11538344.
    Abstract:
    Oligomerization of HCN (1 molar) in the presence of added formaldehyde (0.5 molar) produced an order of magnitude more 8-hydroxymethyladenine than adenine or any other biologically significant purine. This result suggests that on the prebiotic Earth, nucleoside analogs may have been synthesized directly in more complex mixtures of HCN with other aldehydes.
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