These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Terminal deoxynucleotidyl transferase and human leukemia.
    Author: Sahai Srivastava BI.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 Apr; 10(4):715-24. PubMed ID: 1153847.
    Abstract:
    Terminal deoxynucleotidyl transferase activity is as much as several hundred fold greater in acute leukemic lymphoblasts than in unstimulated or phytohemagglutinin stimulated normal lymphocytes, and in leukocytes from other leukemias or from acute lymphoblastic leukemia patients in remission. On the other hand, acute leukemic lymphoblasts and myeloblasts as well as phytohemagglutinin stimulated normal lymphocytes have DNA polymerase activity an order of magnitude higher than that in unstimulated normal lymphocytes, and in leukocytes from chronic leukemias or from acute lymphoblastic leukemia patients in remission. Terminal deoxynucleotidyl transferase thus appears to be a useful index for the detection of leukemic lymphoblasts.
    [Abstract] [Full Text] [Related] [New Search]