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  • Title: Age differences affecting induction of hepatic drug metabolizing enzymes by methaqualone and phenobarbital in the rat.
    Author: Mathur PP, Boren JA, Smyth RD, Reavey-Cantwell NH.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 May; 11(1):39-44. PubMed ID: 1153862.
    Abstract:
    Methaqualone pretreatment for 3 or 6 days caused an induction of hepatic enzymes in the young male rat as measured by a reduction in hexobarbital-hypnosis. However, methaqualone pretreatment had no effect on the hexobarbital-hypnotic response in older male rats. Phenobarbital was a more potent enzyme inducer than methaqualone, and caused induction of liver enzymes in both age groups.
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