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  • Title: Regulation of succinic dehydrogenase activity of heart mitochondria by anti-arrhythmic drugs.
    Author: Sakurada A, Silveirs O, Wambier ML, Brandão D, Campello AP.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 May; 11(1):89-97. PubMed ID: 1153865.
    Abstract:
    It was observed that either propranolol or iproveratril could increase the succinate oxidation activity by rat heart mitochondria to 444% and to 371% respectively. Both drugs decreased the respiratory control coefficient and ADP/O ratio. No effect on mitochondrial succinic dehydrogenase, succinic dehydrogenase-Co Q-reductase and malic dehydrogenase was observed. It was pointed out that these drugs would act preventing the reoxidation of NADH+ + H+ through the respiratory chain.
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