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  • Title: The pharmacokinetics of procainamide in normal subjects using a specific gas chromatographic assay.
    Author: Simons KJ, Levy RH, Cutler RE, Christopher GT, Lindner A.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 Jun; 11(2):173-85. PubMed ID: 1153866.
    Abstract:
    Previous procainamide pharmacokinetic studies have involved the use of colorimetric and fluorimetric methods for the determination of drug concentrations in plasma and urine. However, recent evidence shows that N-acetyl procainamide, the major metabolite in humans, is hydrolyzed during these assay procedures. As a result, a specific gas chromatographic method has been developed for the determination of procainamide in biological fluids. Using this assay procedure, the pharmacokinetics of procainamide were studied in 7 normal subjects following intravenous administration of the drug. The values of half-life (2.08 +/- 0.52 hr), volume of distribution (4.3 +/- 0.6 1/Kg) and total body clearance (1344 +/- 238 ml/min) found in this study differed from those previously reported. These discrepancies could be understood in terms of differences in assay specificity.
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