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  • Title: Experimental studies on effects of simulated weightlessness on myocardial function and structure.
    Author: Zhang LF.
    Journal: J Gravit Physiol; 1994 May; 1(1):P133-6. PubMed ID: 11538742.
    Abstract:
    Recognizing the need to identify and quantify the alterations in myocardial function and structure induced by weightlessness and to clarify the underlying mechanisms, we have devoted ourselves to the present serial work in recent years. To achieve this, firstly, some modifications to the model originally introduced by Morey-Holton and Wronski (1981) were made, so as to make the suspension period prolonged to more than 120 days with least stressful influence and no injurious effects on the tail skin. Secondly, the cardiovascular deconditioning effects of this model were confirmed in conscious rats. Thirdly, changes in myocardial contractile function and ultrastructure after tail-suspension were studied. The main purpose of this paper is to review our recent progress with comments and perspectives.
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