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  • Title: Blood volume regulating hormones response during two space related simulation protocols: four-week confinement and head-down bed-rest.
    Author: Maillet A, Gauquelin G, Gunga HC, Fortrat JO, Kirsch K, Guell A, Bizollon ChA, Gharib C.
    Journal: Acta Astronaut; 1995 Apr; 35(8):547-52. PubMed ID: 11540581.
    Abstract:
    The volume of regulating hormones (renin, aldosterone, arginine vasopressin and atrial natriuretic factor), electrolytes and creatinine concentrations, and blood pressure were measured in two different four-week experimental protocols: respectively -6 degrees head-down bed-rest (5 subjects) and confinement (6 subjects). We observed a significant increase (P < 0.01 at D2 vs D-5) of systolic blood pressure during confinement and a different level of response for some hormones, especially for arginine vasopressin (300% increase during confinement instead of 50% during bed-rest). The renin-angiotensin-aldosterone system was enhanced during confinement and head-down bed-rest. In both conditions, we obtained a similar pattern of response for blood volume regulating hormones. During confinement, two main factors were inactivity and stress activation of the sympathetic nervous system. In the bed-rest study the response is principally due to the fluid shift and blood volume adaptation but it is not possible to exclude the role of inactivity and stress.
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