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  • Title: Familial haemophagocytic reticulosis. Report of 2 cases in sibs.
    Author: Botha JB, Kahn LB, Kaschula RO.
    Journal: S Afr Med J; 1975 Jul 26; 49(32):1305-8. PubMed ID: 1154199.
    Abstract:
    Two cases of familial haemophagocytic reticulosis occurring in sibs are described. The disease is characterised by a widespread proliferation of histocytes showing haemophagocytosis and it usually manifests clinically with haematological abnormalities. The initial presentation may be that of a meningo-encephalitic illness, the result of a lymphohistiocytic infiltration of the meninges and cerebral tissues. The clinical course and pathological features are described and the differential diagnosis is discussed.
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