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  • Title: Two types of foveation strategy in 'latent' nystagmus: fixation, visual acuity and stability.
    Author: Dell'Osso LF, Leigh RJ, Sheth NV, Daroff RB.
    Journal: Neuroophthalmology; 1995 Aug; 15(4):167-86. PubMed ID: 11542501.
    Abstract:
    The authors studied the foveation dynamics of two individuals with latent/manifest latent nystagmus (LMLN) to test the hypothesis that oscillopsia suppression and good visual acuity require periods of accurate target foveation at low slip velocities. Congenital nystagmus (CN) waveforms contain post-saccadic foveation periods; the LMLN waveform does not and yet allows for both oscillopsia suppression and good acuity. During fixation with both eyes open, there were intervals when the eyes were still and correctly aligned; at other times, there was esotropia and nystagmus with slow-phase velocities less than +/- 4 deg/sec and each fast phase pointed the fovea of the fixating eye at the target. However, cover of either eye produced LN and a different strategy was employed: the fast phases carried the fixating eye past the target and the fovea subsequently reacquired it during the slowest parts of the slow phases. The authors confirmed this in both subjects, whose high acuities were made possible by foveation occuring during the low-velocity portions of their slow phases. A nystagmus foveation function (NFF), originally developed for CN, was calculated for both LN and MLN intervals of fixation and it was found to track visual acuity less accurately for individuals with high acuity. Individuals with LMLN exhibit two different foveation strategies: during low-amplitude LMLN, the target is foveated immediately after the fast phases; and during high-amplitude LMLN, target foveation occurs towards the end of the slow phases. Therefore, the saccadic system can be used to create retinal error rather than eliminate it if this strategy is beneficial. Individuals with LMLN foveated targets with the same eye-position and -velocity accuracy as those with CN and the NFF provides a rough estimate of acuity in both. Current calibration methods for both infrared and search-coil techniques need to be altered for subjects with LMLN.
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