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  • Title: [Effects of simulated weightlessness on vasoreactivity of hindlimb arterial bed in rats].
    Author: Ma J, Zhang LN, Zhang LF, Yang TD.
    Journal: Space Med Med Eng (Beijing); 1999 Aug; 12(4):254-7. PubMed ID: 11542705.
    Abstract:
    OBJECTIVE: To investigate the alterations in vasoreactivity of hindlimb arterial bed after simulated weightlessness. METHOD: The tail-suspended rat model was used to simulate weightlessness, and the alterations in vasoreactivity of arterial bed were examined in vitro using isolated, constant flow perfused hindlimb of 2-wk suspended rats and control rats. RESULT: Perfusion flow-pressure relationship of hindlimb arterial bed showed no significant differences between suspended rats and control rats; but vascular responses to KCl (20-100 mM) and PE(10(-8)-10(-4) M) were decreased in hindlimb arterial bed of suspended rats as compared with that of control rats. CONCLUSION: Contractile ability of resistance vessels was diminished in simulated weightlessness rats, and a compromised ability of resistance vessels to increase peripheral resistance may play an important role in occurrence of orthostatic intolerance.
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