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  • Title: [Changes of blood circulation, muscle and skeletal systems in 30 d tail-suspended [correction of tail-suspented] rats].
    Author: Shen XY, Cui W, Ma YL, Dong Q, Wang T, Yang GH.
    Journal: Space Med Med Eng (Beijing); 1999 Aug; 12(4):277-80. PubMed ID: 11542711.
    Abstract:
    OBJECTIVE: To confirm the tail-suspended rat model for the study of countermeasures against weightlessness. METHOD: The changes of blood circulation, muscle and skeletal systems in control group rats (n = 15) and 30 d tail-suspended rats (n = 15) were compared. RESULT: Compared with the control group, the hemorrheology and erythrocyte deformability decreased significantly, muscle-fiber atrophy, muscle contraction function decreased, the type I muscle fibers transformed to the type II muscle fibers, bone-mineral content of L3 and load capacity of femur declined, bone metabolism changed in the suspended rats. CONCLUSION: The tail-suspended rat is a suitable animal model for the study of countermeasures against weightlessness.
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