These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of daily 2-Gz load on human cardiovascular function during weightlessness simulation using 4-day head-down bed rest.
    Author: Sasaki T, Iwasaki KI, Hirayanagi K, Yamaguchi N, Miyamoto A, Yajima K.
    Journal: Uchu Koku Kankyo Igaku; 1999 Sep; 36(3):113-23. PubMed ID: 11543318.
    Abstract:
    An onboard short arm human centrifuge has been proposed as a countermeasure against physiological problems during long exposure to weightlessness in space and during extra planetary exploration. However, there are few studies on the effects of intermittent application of a Gz load via centrifuge during weightlessness. The present study evaluated the effects of a daily 2-Gz load on cardiovascular function during simulated weightlessness using a 4-day head-down bed rest (HDBR) period. Twelve young male subjects were exposed a HDBR period. Eight of them were exposed to a Gz load for up to 30 min twice per day (the Gz group). The remaining 4 were not exposed to a Gz load; they served as controls (the no-Gz group). Compared with the pre-HDBR period, the no-Gz group showed percent changes in the RR interval, the standard deviation (SD) of the RR interval, parasympathetic nervous activity, and baroreflex sensitivity (BRS) that progressively decreased and reached significance at the end of the HDBR period (-5.96 +/- 2.60%, -33.82 +/- 9.60%, -46.3 +/- 12.7% and -30.9 +/- 7.2%, respectively). In the Gz group, however, the percent changes in the RR interval, the SD of the RR interval, parasympathetic nervous activity, and BRS showed no significant changes throughout the HDBR period. At the end of the HDBR period, these indexes were 2.22 +/- 2.21%, -2.31 +/- 12.28%, 5.08 +/- 14.82% and 10.6 +/- 12.5%, respectively, and significantly greater than those of the no-Gz group. Sympathovagal balance indicators showed no significant change in the Gz and no-Gz groups (5.17 +/- 12.85% and 18.5 +/- 10.7%, respectively). These results indicate that a daily load of 2-Gz eliminates reduction of the RR interval, the SD of the RR interval, parasympathetic nervous activity, and BRS, and that it can maintain autonomic cardiovascular function in short-term weightlessness.
    [Abstract] [Full Text] [Related] [New Search]