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  • Title: [Stimulation by insulin of DNA synthesis in cultured mouse fibroblasts].
    Author: Komolov IS, Fedotov VP.
    Journal: Tsitologiia; 1975 Jun; 17(6):723-6. PubMed ID: 1154499.
    Abstract:
    With the aid of autoradiography, the effect of insulin on entering S- from G1-period of the mitotic cycle and on the rate of DNA synthesis of the mouse fibroblasts (L), was studied,--in the cells incubated for 24 hr in serum-free medium. In these conditions the cells were temporarily blocked in G1-period. Insulin (100 mcU/ml) increased by 1.5-fold the amount of cells in S-period as well as caused a marked stimulation of DNA synthesis.
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