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  • Title: [Modulation of behavior of mice of different genotypes by serotonin antibodies].
    Author: Mikovskaia OI, Vetrilé LA, Trekova NA, Basharova LA, Evseev VA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 2001; 51(2):190-6. PubMed ID: 11548600.
    Abstract:
    The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.
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