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  • Title: [Microbial 3-O-demethylation and 3-O-methylation of estratrienes].
    Author: Schubert K, Kaufmann G, Knöll R.
    Journal: Acta Biol Med Ger; 1975; 34(2):167-72. PubMed ID: 1154945.
    Abstract:
    Estradiol-3-methylether, estrone-3-methylether, 17alpha-ethinyl-estradiol-3-methylether and other 17alpha-substituted estratrienes were 3-O-demethylated to free 3-hydroxy compounds by fermentation with Corynebacterium sp. A hydroxy groupp in position 6alpha or 6beta prevented the reaction. The opposite reaction, methylation of the 3-hydroxy group of estratrienes, was performed using Mycobacterium smegmatis. The substrate specifity of this methylation was low. Analogies of these microbial reactions to steroid metabolism in mammalian organism are discussed.
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