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  • Title: Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display.
    Author: Mullaney BP, Pallavicini MG, Marks JD.
    Journal: Infect Immun; 2001 Oct; 69(10):6511-4. PubMed ID: 11553596.
    Abstract:
    Single-chain antibodies neutralize activity and bind nonoverlapping epitopes of botulinum A neurotoxin. Two phage display epitope libraries were constructed from the 1.3 kb of binding domain cDNA. The minimal epitopes selected against the single-chain Fv-Fc antibodies correspond to conformational epitopes with amino acid residues 1115 to 1223 (S25), 1131 to 1264 (3D12), and 889 to 1294 (C25).
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