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  • Title: Actinomyces naeslundii fimbrial protein Orf977 shows similarity to a streptococcal adhesin.
    Author: Hoflack L, Yeung MK.
    Journal: Oral Microbiol Immunol; 2001 Oct; 16(5):319-20. PubMed ID: 11555311.
    Abstract:
    The nucleotide sequence of the chromosomal DNA, upstream of Actinomyces naeslundii T14V fimbrial gene fimA, was determined. One open reading frame (orf977) encoding 977 amino acids was found, preceded by a gene homologous to elongation factor TU. Database searches revealed that Orf977 was homologous to CshA, a Streptococcus gordonii protein involved in cell adhesion. Previous studies had already determined two genes in the type 2 fimbrial gene cluster of A. naeslundii T14V: the structural subunit fimA, and orf365 with unknown function, followed by ribosomal genes. This study completes the type 2 fimbrial gene cluster sequence.
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