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  • Title: Renin secretion from rat renal cortical cell suspensions.
    Author: Lyons HJ, Chruchhill PC.
    Journal: Am J Physiol; 1975 Jun; 228(6):1835-9. PubMed ID: 1155613.
    Abstract:
    Renin secretion of rat renal cortical cell suspensions was studied as a functionof variations in the composition of the suspension media. Renin secretion was determined by incubating samples of the suspension media with rat renin substrate and measuringthe angiotensin I generated by radioimmunoassay. Increasing the medium sodium concentration (50-144 meq/liter) linearly decreased the rate of renin secretion. This relationship was unaffected by adding ouabain (10 minus 3 M) to the suspensions. The addition of furosemide (from 10 minus 5 to 10 minus 3 M) stimulated renin secretion. Considered with previous observations, these results suggest that renin secretionis controlled by some function of sodium on the lumenal boder of the macula densa cells.
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