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  • Title: Hematopoiesis in the embryonic mouse spleen. II. Alterations after phenylhydrazine administration to the mothers.
    Author: Djaldetti M, Bessler H, Fishman P.
    Journal: Anat Rec; 1975 May; 182(1):123-36. PubMed ID: 1155787.
    Abstract:
    The effect of phenylhydrazine (PHZ) on the hematopoietic events in the embryonic spleen of C57Bl/6J mice was examined by light and electron microscopy. Following PHZ in injections to the mothers, the embryonic spleen revealed a marked increase in erythroid precursors, with a shift to mature cells. This phenomenon was part of a more generalized stimulation of erythorpoiesis, expressed by a shift to mature red cell precursors in the embryonic livers and an increase in the percentage of non-nucleated cells in the embryonic peripheral blood. Concomitantly stimulation of phagocytosis in the spleen of embryos in the early gestational days and increased vascularity were observed, and a later effect of granulocytopoietic stimulation. The effect on erythropoiesis in the embryonic spleen might be a sequence of erythropoietin stimulation, either in the mothers or the fetuses, due to anemia and hypoxia following PHZ injections.
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