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  • Title: Subacute cutaneous lupus erythematosus induced or exacerbated by terbinafine: a report of 5 cases.
    Author: Callen JP, Hughes AP, Kulp-Shorten C.
    Journal: Arch Dermatol; 2001 Sep; 137(9):1196-8. PubMed ID: 11559217.
    Abstract:
    BACKGROUND: Subacute cutaneous lupus erythematosus is a nonscarring, non-atrophy-producing photosensitive cutaneous disorder. Half of the patients have 4 or more of the criteria for classification as systemic lupus erythematosus. In some patients, drugs induce or exacerbate the cutaneous disease. OBSERVATION: We describe 5 patients who had either an exacerbation or a new onset of subacute cutaneous lupus erythematosus while taking terbinafine for presumed onychomycosis. CONCLUSION: In general, terbinafine is a safe drug, but perhaps patients with known lupus erythematosus or photosensitivity are predisposed to drug-induced or drug-exacerbated disease.
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