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  • Title: Genetic subtypes of HIV type 1 viruses circulating in the Czech Republic.
    Author: Reinis M, Brucková M, Graham RR, Vandasová J, Stanková M, Carr JK.
    Journal: AIDS Res Hum Retroviruses; 2001 Sep 01; 17(13):1305-10. PubMed ID: 11559432.
    Abstract:
    We analyzed the genetic diversity of HIV-1 strains circulating in the Czech Republic. Phylogenetic analysis of the env and gag gene sequence fragments from 39 isolates revealed that the majority of these strains (32 of 39, 82%) were of subtype B; other genetic subtypes identified were A, C, F, and recombinant circulating form CRF01_AE. The isolates that did not cluster with subtype B originated almost exclusively from a heterosexual route of transmission. The molecular epidemiological data are suggestive of multiple entry of HIV-1 infection into the Czech Republic and show that the genetic pattern of the HIV-1 strains circulating in this country corresponds to that found in other European countries.
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