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  • Title: Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia.
    Author: Castellucci V, Kandel ER.
    Journal: Science; 1976 Dec 10; 194(4270):1176-8. PubMed ID: 11560.
    Abstract:
    Sensitization is an elementary form of nonassociative learning, related to behavioral arousal, in which a strong stimulus facilitates a reflex response. Studies of the neural circuit of the gill-withdrawal reflex in the isolated abdominal ganglion on Aplysia indicate that short-term sensitization is due to presynaptic facilitation. The facilitation results in a sudden increase in the amount of neurotransmitter released by the sensory neurons at their synapses with motor neurons.
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