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  • Title: Evaluation of ketamine HCl for anti-depressant activity.
    Author: Sofia RD, Harakal JJ.
    Journal: Arch Int Pharmacodyn Ther; 1975 Mar; 214(1):68-74. PubMed ID: 1156026.
    Abstract:
    Using several routine screening procedures to determine anti-depressant drug activity in experimental laboratory animals, ketamine HCl was found to possess significant activity over a wide-range of oral doses. The tests used were (a) reversal of tetrabenazine-induced ptosis in mice, (b) reversal of reserpine-induced hypothermia in rats, (c) enhancement of yohimbine toxicity in mice and (d) inhibition of oxotremorine-induced tremors in mice. In general, the anti-depressant potency of ketamine HCl was substantially less than that of imipramine HCl.
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