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  • Title: Antiinflammatory activity of alpha-methyl-3-phenyl-7-benzofuranacetic acid (R-803).
    Author: Swingle KF, Scherrer RA, Grant TJ.
    Journal: Arch Int Pharmacodyn Ther; 1975 Apr; 214(2):240-9. PubMed ID: 1156032.
    Abstract:
    The antiinflammatory activity of R-803 (alpha-methyl-3-phenyl-7-benzofuranacetic acid), a new nonsteroidal drug, has been demonstrated. The oral administration of R-803 inhibits carrageenan-induced edema of the rat's paw, ultraviolet-induced erythema of guinea-pig skin, adjuvant-induced and 6-sulfonamidoindazole-induced arthritides of the rat at doses in the range of 1.0 to 6.0 mg/kg. It also inhibits the cotton pellet-induced granuloma in the rat at higher doses.
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