These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats.
    Author: Chitra KC, Sujatha R, Latchoumycandane C, Mathur PP.
    Journal: Asian J Androl; 2001 Sep; 3(3):205-8. PubMed ID: 11561191.
    Abstract:
    AIM: To find out the changes induced by lindane on the antioxidant enzymes in epididymis and epididymal sperm of adult rats. METHODS: Adult male rats were orally administered lindane at a dose of 5.0 mg/kg body weight per day for 30 days. At the end of the treatment, the rats were sacrificed. The epididymis was removed and weighed and sperm were collected for sperm count, motility and biochemical studies. A 1% homogenate of epididymis was prepared and used for biochemical estimations. RESULTS: In lindane-treated rats, there were significant reductions in the epididymal weight, epididymal sperm count and motility compared with the controls. Significant decreases in the superoxide dismutase (SOD), catalase, glutathione reductase and glutathione peroxidase activities and significant increases in the H2O2 generation and lipid peroxidation were also observed in the epididymis and epididymal sperm of lindane-treated rats. CONCLUSION: Lindane decreases the levels of antioxidant enzymes in the epididymis and epididymal sperm of adult rats thereby inducing oxidative stress.
    [Abstract] [Full Text] [Related] [New Search]