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  • Title: Arrhythmicity in a child with septo-optic dysplasia and establishment of sleep-wake cyclicity with melatonin.
    Author: Rivkees SA.
    Journal: J Pediatr; 2001 Sep; 139(3):463-5. PubMed ID: 11562632.
    Abstract:
    We identified a 3-year-old child with septo-optic dysplasia with arrhythmic activity patterns. To assess whether melatonin could improve rest-activity patterns, 0.1 mg was administered orally at 19:00 hours. After therapy onset, normal rest-activity patterns appeared. These observations show that melatonin can restore normal rhythmicity in the absence of a normally functioning circadian clock.
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