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  • Title: Preparation of 3'-C-branched uridine analogues, suitable for conversion into functionalised 3'-C-methylene derivatives.
    Author: Winqvist A, Strömberg R.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):1389-92. PubMed ID: 11563029.
    Abstract:
    A novel method for preparation of 1-[2-O-(tert-butyldimethylsilyl)-3- deoxy-3-C-hydroxymethyl-5-O-monomethoxytrityl-beta-D-ribo- pentofuranosyl]uracil by hydroboration of corresponding 3'-deoxy-3'-C-methyleneuridine derivative has been developed. Further conversion of the hydroxyl function into different leaving groups was carried out to afford derivatives suitable for conversion into various 3'-C-branched uridine analogues through substitution.
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