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  • Title: Synthesis and antiviral activity of D- and L-2'-azido-2',3'-dideoxy-4'-thiopyrimidine and purine nucleosides.
    Author: Jeong LS, Kim YH, Kim HO, Yoo SJ, Park YH, Yeon SH, Chun MW, Kim HD.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):665-8. PubMed ID: 11563087.
    Abstract:
    Novel D- and L-2'-azido-2',3'-dideoxy-4'-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 micrograms/ml.
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