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  • Title: Novel propargylamine-linked nucleosides for high throughput SNP genotyping by MALDI-TOF MS.
    Author: Wenzel T, Fröhlich T, Strassburger K, Richter S, Bimmler J, Franke C, Thomas I, Kostrzewa M.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):883-7. PubMed ID: 11563137.
    Abstract:
    The synthesis of positively charged and mass tagged nucleosides containing a quaternary ammonium functionality within the penultimate position of a primer is described. Neutralization of the sugar/thiophosphate backbone by alkylation increases the detection sensitivity in the mass spectrometric analysis by a factor of at least 100. The variable introduction of these novel compounds within the extension primers enables flexible design of multiplex genotyping reactions.
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