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  • Title: Benzyl-functionalized cycloSal-d4T monophosphates.
    Author: Renze J, Plath M, Ducho C, Balzarini J, De Clercq E, Meier C.
    Journal: Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):931-4. PubMed ID: 11563147.
    Abstract:
    Synthetic routes to benzyl-functionalized cycloSal-d4T monophosphates (7CH2X-cycloSal-d4TMP) have been developed. Their hydrolytic behavior in basic aqueous solution (pH = 7.3) was studied and their hydrolysis half-lives were determined. It turned out that two different degradation pathways are leading to different products: beside the formation of the expected d4TMP and a styrene type derivative, a phenyl-d4T-phosphodiester was obtained as well. The product distribution was specified.
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