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  • Title: Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro.
    Author: Wilson RJ, Allen MJ, Nandi M, Giles H, Thornton S.
    Journal: BJOG; 2001 Sep; 108(9):960-6. PubMed ID: 11563467.
    Abstract:
    OBJECTIVES: To determine whether: 1. oxytocin receptor antagonists influence spontaneous contractions of myometrium from humans, non-human primates and rodents (in vitro), and 2. vasopressin V1a receptor antagonism is important for inhibition of spontaneous contractions in human myometrium. DESIGN: In vitro pharmacology of spontaneous contractions of myometrium from humans and animals. SETTING: The research laboratories of a university department of obstetrics and gynaecology and a pharmaceutical industry research centre. INTERVENTIONS: Samples of human myometrium were obtained at caesarean section. Tissue strips were suspended in organ baths for isometric force recording. Cumulative concentration effect curves to a selective oxytocin receptor antagonist (L-371,257) and a mixed oxytocin/vasopressin V1a receptor antagonist (atosiban) were obtained. The effect of L-371,257 was also determined in myometrium from non-pregnant rats and marmosets. MAIN OUTCOME MEASURES: The inhibition of spontaneous myometrial contractions in vitro. RESULTS: L-371,257 and atosiban significantly inhibited spontaneous activity of human myometrium in a concentration-related manner (P < 0.05), although the effect was more pronounced with L-371,257. Spontaneous contractions of myometrium from non-pregnant rats and marmosets were also inhibited by L-371,257 (atosiban was not tested). CONCLUSIONS: Spontaneous contractions of myometrium from humans, marmosets and rats are, at least in part, dependent on oxytocin receptor activity, in vitro. L-371,257 and atosiban may be inverse agonists. Selective non-peptide oxytocin receptor antagonists may be effective tocolytics.
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