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  • Title: Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT.
    Author: Isayama S, Sugimoto Y, Nishiga M, Kamei C.
    Journal: Jpn J Pharmacol; 2001 Aug; 86(4):451-3. PubMed ID: 11569620.
    Abstract:
    We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.
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